Because grapefruit permanently prevents the enzyme from breaking down the drugs, the body must manufacture more enzymes. Grapefruit inactivates an enzyme that metabolizes many drugs. These problems can occur with grapefruit, grapefruit juice, even marmalade with grapefruit in it. Other types of drugs that interact with grapefruit include some pain relievers, sedatives, and drugs for prostate enlargement. Some of these cancer drugs are erverolimus, dasatinib, and vemurafenib. In these cases, the risk is a dangerous, irregular heart rhythm (Torsade de pointes), plus muscle damage. Hallucinations and seizures can result from combining dextromethorphan, a cough suppressant, with grapefruit.Īt least ten chemotherapy drugs can interact with grapefruit. Nifedipine (Procardia ®), taken for high blood pressure, can interact with grapefruit to cause very low blood pressure. Breakdown products from damaged muscles may damage the kidneys.Įrythromycin, a common antibiotic, can cause a dangerous heart rhythm if taken with grapefruit. The muscle damage results in muscle pain and tenderness. Atorvastatin (Lipitor ®), lovastatin (Mevacor ®) and simvastatin (Zocor ®) are known to interact with grapefruit. These are drugs used to treat high cholesterol. Perhaps the most well-known example is muscle damage caused by some statins. These include dangerous heart rhythms, kidney damage, muscle damage, respiratory depression, and bleeding from the stomach or intestines. More than half of them can cause very serious effects. Eighty-five drugs are known or suspected to interact with grapefruit. We've known for twenty years it's not safe to mix grapefruit and some prescription drugs. The list of medicines known to interact with grapefruit has grown longer. Do you love that morning glass of grapefruit juice? If you take certain medicines, it might not love you back.
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